When talking about dietary supplements, especially medicinal mushrooms, bioavailability is a very important concept. This notion determines the real effectiveness of your supplements, whether they are cordyceps in capsules or reishi powder for example. Do you want to know more? At French Mush, no secrets! We explain in detail what you need to remember about this key concept.
Bioavailability: what it actually is❓
Bioavailability refers to the speed and extent of the passage of an active substance into the general circulation. In other words, it is the fraction of the product that actually reaches your bloodstream and can exert its therapeutic effect. For the chaga mushroom, for example, this represents the amount of antioxidants that actually reaches your cells. When talking about the Lion's Mane mushroom (Hericium erinaceus), bioavailability refers to the ability of its bioactive compounds, particularly hericenones and beta-glucans, to be effectively absorbed by the body.
Concerning other medicinal mushrooms, we observe similar mechanisms:
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Reishi : Its bioavailability is significantly improved by our extraction method, with a concentration of 90% in polysaccharides including 70% beta-glucans.
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Cordyceps : Absorption is well optimized, which preserves its bioactive compounds like adenine and cordycepin.
The notion of bioavailability is particularly important, because it determines not only the effectiveness of a product, but also its actual therapeutic value. A medicinal mushroom may contain extraordinary compounds, but without good bioavailability, they will not be able to exert their beneficial effects.
What is the route of molecules from food supplements in your body?
Are you wondering how it actually works? The journey of a supplement based on medicinal mushroom in your body is fascinating. To tell you the truth, each step is crucial:
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Absorption: crossing the intestinal barrier, a particularly delicate step for molecules;
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Distribution: circulation in the blood system via the hepatic portal system (pathway transporting blood from the digestive organs to the liver);
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Metabolism: transformation by the liver (first hepatic passage);
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Elimination: disposal of unused compounds.
And that’s not all! Each step directly influences the final effectiveness of your supplement. This is why we have adopted the ultrasonic extraction method which optimizes the bioavailability of our products up to 92%.
What are the determining factors of bioavailability?
You may think that bioavailability only depends on the product? Think again! Many other factors come into play.
Product characteristics
The intrinsic characteristics of the product mainly influence its level of bioavailability. 🍄 Among these characteristics, we have in particular:
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Physico-chemical properties: solubility, degree of ionization, size of molecules;
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The extraction method (our revolutionary ultrasound technology);
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Genic form (powder, capsule, liquid extract);
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The presence of excipients and their interaction with the active ingredients.
It should be noted that the dosage form plays a particularly important role in bioavailability, because it directly influences the speed and efficiency of absorption.
Physiological factors
Your body also plays a significant role in this equation. At this level, we note factors such as:
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Age and metabolism;
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The state of digestive function (gastric pH, intestinal motility);
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The timing of intake in relation to meals, because nutrients are well absorbed in the presence of food;
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Interactions with food or other substances;
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Possible pathologies (achlorhydria, malabsorption syndrome);
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Previous surgical procedures on the digestive system.
These factors, which depend on the body of each individual, can significantly modify the bioavailability of the same product from one person to another.
Ultrasonic extraction, our secret for almost total bioavailability 🚀
Our ultrasonic extraction method is a real asset for our products, whether it is the cordyceps in capsules or the lion’s mane powder for example. This technology allows for an exceptional bioavailability of 92%, a remarkable rate compared to traditional methods.
Adaptogenic mushrooms such as reishi, cordyceps or chaga for example, contain complex compounds (triterpenes, polysaccharides) which require sophisticated extraction. Our ultrasound technology therefore allows us to preserve the integrity of these molecules while optimizing their bioavailability.
How to measure bioavailability? 📊
Bioavailability is measured scientifically using several pharmacokinetic parameters:
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Cmax: maximum plasma concentration reached
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Tmax: time required to reach this maximum concentration
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AUC (Area Under the Curve) or ASC (Area Under the Curve): represents the total exposure of the body to the active compound
Credits : EUPATI
These measurements make it possible to precisely assess the bioavailability of a product and its bioequivalence with other formulations. The area under the plasma concentration-time curve is particularly important, as it directly reflects the amount of active substance available in the body.
Conclusion: the synergy between nature and science
Bioavailability is the key factor that determines how effective your adaptogenic mushroom supplements actually are. Our ultrasonic extraction technology, combined with an in-depth understanding of bioavailability mechanisms, allows us to offer products whose effectiveness is optimized and scientifically proven.
By choosing our extracts, you benefit from a unique synergy between the ancestral wisdom of medicinal mushrooms and modern scientific innovation.
Sources:
Bioavailability of Drugs - Clinical Pharmacology - Merck Manuals Professional Edition
https://www.msdmanuals.com/fr/professional/pharmacologie-clinique/pharmacocin%C3%A9tique/biodisponibilit%C3%A9-des-m%C3%A9dicaments
Bioavailability: what is it?
https://www.futura-sciences.com/sante/definitions/medicaments-biodisponibilite-3064/